Transmission/Disequilibrium Tests for Multiallelic Loci
نویسندگان
چکیده
منابع مشابه
Application to Estimate Haplotypes for Multiallelic Present-Absent Loci
The article presents an algorithm and an application to estimate haplotype frequencies from genotype data for unrelated individuals. Presented approach can handle loci with multiple alleles as well as silent (null) alleles. The mathematical model and an expanded Expectation-Maximization algorithm is described. The computer program, called NullHap, available freely at http://staff.elka.pw.edu.pl...
متن کاملSampling variance and distribution of the D' measure of overall gametic disequilibrium between multiallelic loci.
The development of the theory of estimation of gametic disequilibrium for multiallelic systems is particularly necessary, since a large number of the genetic markers available at present are highly polymorphic multiallelic systems. The D' coefficient is one of the most commonly used measures of the extent of overall disequilibrium between all possible pairs of alleles at two multiallelic loci. ...
متن کاملLandscape genomic tests for associations between loci and environmental gradients
Adaptation to local environments often occurs through natural selection acting on a large number of alleles, each having a weak phenotypic effect. One way to detect these alleles is to identify genetic polymorphisms that exhibit high correlation with environmental variables used as proxies for ecological pressures. Here we propose an integrated framework based on population genetics, ecological...
متن کاملPermutation tests for multiple loci affecting a quantitative character.
The problem of detecting minor quantitative trait loci (QTL) responsible for genetic variation not explained by major QTL is of importance in the complete dissection of quantitative characters. Two extensions of the permutation-based method for estimating empirical threshold values are presented. These methods, the conditional empirical threshold (CET) and the residual empirical threshold (RET)...
متن کاملModeling multiallelic selection using a Moran model.
We present a Moran-model approach to modeling general multiallelic selection in a finite population and show how it may be used to develop theoretical models of biological systems of balancing selection such as plant gametophytic self-incompatibility loci. We propose new expressions for the stationary distribution of allele frequencies under selection and use them to show that the continuous-ti...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The American Journal of Human Genetics
سال: 1997
ISSN: 0002-9297
DOI: 10.1016/s0002-9297(07)64343-2